A suspected case of hypoxia-induced pre-renal azotemia in an old part-Arab stallion: case report and review of the literature

  • Onyinyechukwu A. AGINA University of Nigeria, Faculty of Veterinary Medicine, Department of Veterinary Pathology and Microbiology, Nsukka
  • Ezinne C. ANI University of Nigeria, Faculty of Veterinary Medicine, Department of Veterinary Pathology and Microbiology, Nsukka
Keywords: hematology; hypoxia; serum biochemistry; old stallion; part-Arab; pre-renal azotemia

Abstract

The kidneys maintain homeostasis and this function is compromised in hypoxic conditions. Hematology and serum biochemistry evaluations were performed on a 17-year old Nigerian part-Arab stallion, who was observed to be docile, cachexic, and has bilateral ocular mucus discharge. Ticks were seen attached around the inguinal region. The mucous membrane of the eyes was congested, animal was partially insensitive to its environment and had an abnormal posture and gait. Blood samples for hematology and clinical biochemistry analyses were collected from the jugular vein. Hematology and serum biochemistry determinations followed standard procedures. Hematological analysis revealed that the stallion had secondary absolute polycythemia, low erythrocyte sedimentation rate. The mean corpuscular volume, mean corpuscular hemoglobin concentration and total leukocyte count were within the respective reference ranges. The clinical biochemistry profile of the horse showed normal serum activity of alanine aminotransferase and elevated serum activities of aspartate aminotransferase and alkaline phosphatase, normal serum total protein, albumin, decreased serum globulin concentrations, with a high albumin: globulin (A/G) ratio. The stallion also had normal total cholesterol level and an abnormally high serum creatinine and blood urea nitrogen levels. These findings were suggestive of hypoxia-induced pre-renal azotemia.

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References

Agina OA (2017). Haematology and clinical biochemistry findings associated with equine diseases - a review. Notulae Scientia Biologicae 9(1):1-21. https://doi.org/10.15835/nsb919939

Chen J, Al Khalili Y (2020). Physiology, osmoregulation and excretion. StatPearls Publishing, Treasure Island.

Durno AS, Webb JA, Gauthier MJ, Bienzle D (2011). Polycythemia and inappropriate erythropoietin concentrations in two dogs with renal T-cell lymphoma. Journal of American Animal Hospital Association 47(2):122-128. https://doi.org/10.5326/JAAHA-MS-5614

Evans RG (2019). Another step forward for methods for studying renal oxygenation. Kidney International 96(3):552-554. https://doi.org/10.1016/j.kint.2019.05.010

Haase VH (2013). Regulation of erythropoiesis by hypoxia-inducible factors. Blood Reviews 27(1):41-53. https://doi.org/10.1016/j.blre.2012.12.003

Hirakawa Y, Tanaka T, Nangaku M (2017). Renal hypoxia in CKD: pathophysiology and detecting methods. Frontiers in Physiology 8:1-10. https://doi.org/10.3389/fphys.2017.00099

Hounkpatin HO, Fraser SDS, Glidewell L (2019). Predicting risk of recurrent acute kidney injury: a systematic review. Nephron 142:83-90. https://doi.org/10.1159/000497385

Jing H, Hsu W-L, Wu V-C (2020). Urine hemojuvelin in cats with naturally occurring kidney disease. Journal of Veterinary Internal Medicine 1-9. https://doi.org/10.1111/jvim.15781

Kuo W, Kurtcuoglu V (2017). Renal arteriovenous oxygen shunting. Current Opinion in Nephrology and Hypertension 26(4):290-295. https://doi.org/10.1097/MNH.0000000000000332

Łuszczyński J, Pieszka M, Petrych W, Stefaniuk-Szmukier M (2019). The frequency of errors in determining age based on selected features of the incisors of icelandic horses. Animals 9(6):298. https://doi.org/10.3390/ani9060298

Manoeuvrier G, Bach-Ngohou K, Batard E (2017). Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department. BMC Nephrology 18(1):173. https://doi.org/10.1186/s12882-017-0591-9

Nordquist L, Friederich-Persson M, Fasching A (2015). Activation of hypoxia-inducible factors prevents diabetic nephropathy. Journal of American Society of Nephrology 26(2):328-338. https://doi.org/10.1681/ASN.2013090990

Okoro RN, Farate VT (2019). The use of nephrotoxic drugs in patients with chronic kidney disease. International Journal of Clinical Pharmacology 41(3):767-775. https://doi.org/10.1007/s11096-019-00811-9

Safran M, Kim WY, O’Connell F (2006). Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production. Proceedings of the National Academy of Sciences of the United States of America 103(1):105-110. https://doi.org/10.1073/pnas.0509459103

Samanta A, Patra A, Mandal S (2018). Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology. Saudi Journal of Kidney Disease and Transplantation 29(4):879. https://doi.org/10.4103/1319-2442.239653

Suganya, Shanmuga Priya R, Rajini Samuel T, Rajagopalan B (2016). A study to evaluate the role of bun/creatinine ratio as a discriminator factor in azotemia. International Journal of Pharmaceutical Science Review and Research 40:131-134.

Walton RM (2014) Equine clinical pathology. Wiley Blackwell, Ames, Iowa pp 203-218.

Published
2020-06-29
How to Cite
AGINA, O. A., & ANI, E. C. (2020). A suspected case of hypoxia-induced pre-renal azotemia in an old part-Arab stallion: case report and review of the literature. Notulae Scientia Biologicae, 12(2), 460-465. https://doi.org/10.15835/nsb12210637
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