TY - JOUR AU - OMEKE, Jacinta N. AU - AGINA, Onyinyechukwu A. AU - IHEDIOHA, John I. AU - ANAGA, Aruh O. AU - EZEMA, Wilfred S. AU - Okoye, John PY - 2021/11/02 Y2 - 2024/03/28 TI - Haemato-biochemical alterations and acute toxicity study of hydro-methanol root extract of Anacardium occidentale in cockerels JF - Notulae Scientia Biologicae JA - Not Sci Biol VL - 13 IS - 4 SE - Research articles DO - 10.15835/nsb13410727 UR - https://www.notulaebiologicae.ro/index.php/nsb/article/view/10727 SP - 10727 AB - <p>The study evaluated the haemato-biochemical alterations and acute toxicity of hydro-methanol root extract of <em>Anarcaduim occidentale </em>(AO) in cockerels. Forty chickens randomly assigned into four groups (A, B, C and D) of 10 birds each were used for the experiment. Groups A, B, C and D received 3000, 1500 and 500 mg/kg body weight of the extract and distilled water respectively. Relative weights, haematology, serum biochemistry, gross and histopathological features of the lymphoid organs of chickens were studied. No significant (<em>P</em>&gt;0.05) variation was observed in their body weights. The white blood cell count of group A chicken were significantly (<em>P</em>&lt;0.05) lower than that of groups B and C chickens. Serum biochemistry tests revealed significant (<em>P</em>&lt;0.05) variations at different doses for the alanine aminotransferase, alkaline phosphatase, serum total protein, albumin, cholesterol, triacylglycerol, uric acid, creatinine, calcium and phosphorus activities when compared to the control group.&nbsp; Gross and histopathological examinations showed no overt alterations in the tissues examined. It was observed that varied doses of root extract of <em>Anarcaduim occidentale</em> caused significant decrease in haematology and serum biochemistry parameters of chickens and no obvious lesions in internal organs.</p> ER -