TY - JOUR AU - AKOGWU, Martins S. AU - UCHENDU, Chukwuka N. AU - ODO, Rita I. PY - 2020/12/21 Y2 - 2024/03/28 TI - The influence of human chorionic gonadotropin on hormonal and haematological profile of postpubertal male albino rats exposed to chronic oral administration of alcohol JF - Notulae Scientia Biologicae JA - Not Sci Biol VL - 12 IS - 4 SE - Research articles DO - 10.15835/nsb12410718 UR - https://www.notulaebiologicae.ro/index.php/nsb/article/view/10718 SP - 773-780 AB - <p style="text-align: justify;">This study evaluated the influence of human chorionic gonadotropin on hormonal and haematological profile of postpubertal male albino rats exposed to chronic oral administration of alcohol. Twenty-four mature male albino rats were assigned to four groups (n=6). Group A was the control, given distilled water, Group B was given 30% ethanol (8 ml/kg) orally 3 times a week, Group C was given human chorionic gonadotropin (HcG) (50 IU/kg) subcutaneously 3 times a week and Group D was given HcG (50 IU/kg) subcutaneously + 30% ethanol (8 ml/kg) orally 3 times a week. The study was for 10 weeks, and hormonal profile and haematology were determined. The follicle stimulating hormone of Group B decreased significantly (P&lt;0.05) when compared to Groups A, C and D. The luteinizing hormone was significantly lower (P&lt;0.05) in Group B when compared to Groups A, C and D. The testosterone level was significantly higher (P&lt;0.05) in Group D when compared to Groups A, B and C. The results obtained from haematology indicated that haemoglobin concentration of Group B was significantly lower (P&lt;0.05) when compared to Groups A, C and D. Ethanol significantly reduced (P&lt;0.05) platelets when compared to Groups A, C and D. There was a significant reduction (P&lt;0.05) in the neutrophils and lymphocytes in Group B when compared to Groups A, C and D. The study showed that HcG improves the level of male hormones and haematology in postpubertal albino rats exposed to chronic alcohol administration.</p> ER -