@article{OLOYEDE_LUKMAN_SALAWU_2020, title={Protective potentials of ethyl acetate-ethanolic fraction of Carica papaya leaves against acetaminophen-induced liver damage in rats}, volume={12}, url={https://www.notulaebiologicae.ro/index.php/nsb/article/view/10629}, DOI={10.15835/nsb12310629}, abstractNote={<p style="text-align: justify;">The liver is an important organ performing vital roles that become affected when damaged. The protective potential of ethyl acetate-ethanolic fraction of <em>Carica papaya </em>leaves on acetaminophen-induced liver damage in female albino rats was investigated. Forty female rats were completely randomized into eight groups (A-H) of five rats each. Group A (control), received 1 ml of distilled water, group B (untreated) received 250 mgkg<sup>-1</sup>  bw of acetaminophen, group C received  silymarin (50 mgkg<sup>-1</sup> bw) followed by actaminophen (250 mgkg<sup>-1</sup> bw),  groups D-G received 100, 200, 400 and 600 mgkg<sup>-1</sup>  bw of ethyl acetate-ethanolic fraction of <em>Carica papaya</em> leaves respectively; followed by acetaminophen administration (250 mgkg<sup>-1</sup> bw), while group H (toxicity control) received 600 mgkg<sup>-1</sup> bw extract fraction daily. Ethyl acetate-ethanolic fraction of <em>Carica papaya</em> leaves significantly (p<0.05) decreased the activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and bilirubin concentration and increased the concentrations of total protein and albumin in acetaminophen-induced liver damaged rats when compared with the untreated group. Prevention of liver damage was observed in the groups pre-administered 400 and 600 mgkg<sup>-1</sup> bw of the extract fraction as well as the silymarin group. Activities of superoxide dismutase and catalase and the concentration of glutathione were significantly (p<0.05) increased while the concentration of malondialdehyde was significantly (p<0.05) decreased in rats pre-administered with silymarin or the extract fraction when compared with the acetaminophen-induced rats. Ethyl acetate-ethanolic fraction of <em>Carica papaya</em> leaves prevented acetaminophen-induced rat liver damage probably mainly due to the antioxidant constituents of the fraction.</p>}, number={3}, journal={Notulae Scientia Biologicae}, author={OLOYEDE, Hussein O. B. and LUKMAN, Halimat Y. and SALAWU, Musa O.}, year={2020}, month={Sep.}, pages={556–567} }