Discoidin Domain Receptors Role in Human Diseases

Authors

  • Iker BADIOLA University of the Basque Country, Faculty of Medicine, Department of Cell Biology, Bº Sarriena sn 48940, Leioa Bizkaia

DOI:

https://doi.org/10.15835/nsb346455

Abstract

Discoidin Domain Receptor 1 and Discodin Domain Receptor 2 are the two only members of the DDR family. The DDR family is a Tyrosine Kinase Receptor (TKR) family with some peculiarities compared with other Tyrosine Kinase Receptors such as their natural ligand; which in this case is the fibrillar collagen; or the slow phosphorylation pattern. These peculiarities confer a special role to the receptors present in many diseases development processes as cancer, cirrhosis or lung fibrosis. In this review it is described the overview of the DDRs structure and their role in the different disease development and the possibility to consider them as therapeutic targets.

Author Biography

Iker BADIOLA, University of the Basque Country, Faculty of Medicine, Department of Cell Biology, Bº Sarriena sn 48940, Leioa Bizkaia

Director of Product Development

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Published

2011-11-17

How to Cite

BADIOLA, I. (2011). Discoidin Domain Receptors Role in Human Diseases. Notulae Scientia Biologicae, 3(4), 07–12. https://doi.org/10.15835/nsb346455

Issue

Section

Review articles

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