The influence of Staphylococcus infections on the evolution of hospitalized patients: The experience of the surgical department of IRGH Cluj-Napoca

  • Corina M. CRISAN Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca; Prof. Dr. O. Fodor Regional Institute of Gastroenterology and Hepatology, 5 Constanta Street, 400158 Cluj-Napoca (RO)
  • Stanca L. PANDREA Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca; Prof. Dr. O. Fodor Regional Institute of Gastroenterology and Hepatology, 5 Constanta Street, 400158 Cluj-Napoca (RO)
  • Manuela TOMPA Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca; Prof. Dr. O. Fodor Regional Institute of Gastroenterology and Hepatology, 5 Constanta Street, 400158 Cluj-Napoca (RO)
  • Teodora MOCAN Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca; Prof. Dr. O. Fodor Regional Institute of Gastroenterology and Hepatology, 5 Constanta Street, 400158 Cluj-Napoca (RO)
  • Aida PUIA Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca (RO)
  • Lucian MOCAN Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca; Prof. Dr. O. Fodor Regional Institute of Gastroenterology and Hepatology, 5 Constanta Street, 400158 Cluj-Napoca (RO)
Keywords: antibiotic treatment, bacterial infection, Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA)

Abstract

Despite recent scientific advances in diagnosis and treatment of human infections, bacterial infections continue to affect human health. The rate of morbidity and mortality caused by staphylococcal infections remains high and continues to be a threat to public health worldwide. Staphylococcal infections affect the population at risk regardless the level of country development. The highest risk categories include people with immunodeficiency, those with prolonged antibiotic treatment and repeated hospitalizations, patients with implanted medical devices or undergoing medical invasive procedures. The objective of this study was to analyse the influence of staphylococcal infection diagnosed during hospitalization on the evolution of patients admitted during two consecutive years, in surgical and intensive care wards in IRGH (Regional Institute of Gastroenterology and Hepatology) Cluj-Napoca, Romania, having as main diagnosis of hospitalization surgical digestive diseases along with other comorbidities. The occurrence of staphylococcal infection was associated with increased morbidity and mortality rates in patients included in the study.

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References

Algammal AM, Hetta HF, Elkelish A, Alkhalifah DHH, Hozzein WN, Batiha GES, ... Mabrok MA (2020). Methicillin-Resistant Staphylococcus aureus (MRSA): one health perspective approach to the bacterium epidemiology, virulence factors, antibiotic-resistance, and zoonotic impact. Infection and Drug Resistance 13:3255. https://doi.org/10.2147/IDR.S272733

Brown NM, Goodman AL, Horner C, Jenkins A, Brown EM (2021). Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK. JAC-Antimicrobial Resistance 3(1):dlaa114. https://doi.org/10.1093/jac/dkab036

Cong Y, Yang S, Rao X (2020). Vancomycin resistant Staphylococcus aureus infections: A review of case updating and clinical features. Journal of Advanced Research 21:169-176. https://doi.org/10.1016/j.jare.2019.10.005

Foster T (1996). Staphylococcus. Medical Microbiology. 4th edition.

Gajdács M (2019). The continuing threat of methicillin-resistant Staphylococcus aureus. Antibiotics 8(2):52. https://doi.org/10.3390/antibiotics8020052

Gao C, Fan YL, Zhao F, Ren QC, Wu X, Chang L, Gao F (2018). Quinolone derivatives and their activities against methicillin-resistant

Staphylococcus aureus (MRSA). European Journal of Medicinal Chemistry 157:1081-1095. https://doi.org/10.1016/j.ejmech.2018.08.061

Gould IM (2007). MRSA bacteraemia. International Journal of Antimicrobial Agents 30:66-70.

Graninger W, Wenisch C, Hasenhundl M (1995). Treatment of staphylococcal infections. Current Opinion in Infectious Diseases 8:S20-S28. https://doi.org/10.1136/bmj.330.7498.976

Guo Y, Song G, Sun M, Wang J, Wang Y (2020). Prevalence and therapies of antibiotic-resistance in Staphylococcus aureus. Frontiers in Cellular and Infection Microbiology 10:107. https://doi.org/10.3389/fcimb.2020.00107

Harbarth S, Von Dach E, Pagani L, Macedo-Vinas M, Huttner B, Olearo F, ... Uçkay I (2015). Randomized non-inferiority trial to compare trimethoprim/sulfamethoxazole plus rifampicin versus linezolid for the treatment of MRSA infection. Journal of Antimicrobial Chemotherapy 70(1):264-272. https://doi.org/10.1093/jac/dku352

Harris LG, Foster SJ, Richards RG (2002). An introduction to Staphylococcus aureus, and techniques for identifying and quantifying S. aureus adhesins in relation to adhesion to biomaterials: review. European Cells and Materials 4(3):100-20. https://doi.org/10.22203/eCM.v004a04

Hassoun A, Linden PK, Friedman B (2017). Incidence, prevalence, and management of MRSA bacteremia across patient populations – a review of recent developments in MRSA management and treatment. Critical Care 21(1):1-10. https://doi.org/10.1186/s13054-017-1801-3

Khan TM, Kok YL, Bukhsh A, Lee LH, Chan KG, Goh BH (2018). Incidence of methicillin resistant Staphylococcus aureus (MRSA) in burn intensive care unit: a systematic review. Germs 8(3):113. https://doi.org/10.18683/germs.2018.1138

Kourtis AP, Hatfield K, Baggs J, Mu Y, See I, Epson E, ... Cardo D (2019). Vital signs: epidemiology and recent trends in methicillin-resistant and in methicillin-susceptible Staphylococcus aureus bloodstream infections—United States. Morbidity and Mortality Weekly Report 68(9):214. https://doi.org/10.15585/mmwr.mm6809e1

Lee AS, De Lencastre H, Garau J, Kluytmans J, Malhotra-Kumar S, Peschel A, Harbarth S (2018). Methicillin-resistant Staphylococcus aureus. Nature Reviews Disease Primers 4(1):1-23. https://doi.org/10.1038/nrdp.2018.33

Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, ... Chambers HF (2011). Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clinical Infectious Diseases 52(3):e18-e55. https://doi.org/10.1093/cid/ciq146

Matthews KR, Roberson J, Gillespie BE, Luther DA, Oliver SP (1997). Identification and differentiation of coagulase-negative Staphylococcus aureus by polymerase chain reaction. Journal of Food Protection 60(6):686-688. https://doi.org/10.4315/0362-028X-60.6.686

Myles IA, Datta SK (2012). Staphylococcus aureus: an introduction. In: Seminars in Immunopathology. Springer-Verlag, 34(2):181-184.

Oliveira D, Borges A, Simões M (2018). Staphylococcus aureus toxins and their molecular activity in infectious diseases. Toxins 10(6):252. https://doi.org/10.3390/toxins10060252

Rubinstein E, Keynan Y (2014). Vancomycin revisited–60 years later. Frontiers in Public Health 2:217. https://doi.org/10.3389/fpubh.2014.00217

Rybak MJ, Le J, Lodise TP, Levine DP, Bradley JS, Liu C, ... Lomaestro B (2020). Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: a revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Clinical Infectious Diseases 71(6):1361-1364. https://doi.org/10.1093/ajhp/zxaa036

Sharaf MH, El-Sherbiny GM, Moghannem SA, Abdelmonem M, Elsehemy IA, Metwaly AM, Kalaba MH (2021). New combination approaches to combat methicillin-resistant Staphylococcus aureus (MRSA). Scientific Reports 11(1):1-16. https://doi.org/10.1038/s41598-021-82550-4

Siddiqui AH, Koirala J (2021). Methicillin resistant Staphylococcus aureus. In: StatPearls [internet]. StatPearls Publishing.

Taylor TA, Unakal CG (2017). Staphylococcus aureus. StatPearls. Publishing: Treasure Island, FL, USA.

Tong SY, Schaumburg F, Ellington MJ, Corander J, Pichon B, Leendertz F, ... Giffard PM (2015). Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov. International Journal of Systematic and Evolutionary Microbiology 65(Pt 1):15. https://doi.org/10.1099/ijs.0.062752-0

Published
2022-09-23
How to Cite
CRISAN, C. M., PANDREA, S. L., TOMPA, M., MOCAN, T., PUIA, A., & MOCAN, L. (2022). The influence of Staphylococcus infections on the evolution of hospitalized patients: The experience of the surgical department of IRGH Cluj-Napoca . Notulae Scientia Biologicae, 14(3), 11332. https://doi.org/10.55779/nsb14311332
Section
Research articles
CITATION
DOI: 10.55779/nsb14311332