Biological characteristics and mortality in patients with diabetes and COVID-19

  • Nousseiba ABED University of Brothers Mentouri, Laboratory of Pharmacology and Toxicology, Constantine; University of Brothers Mentouri, Laboratory of Cellular and Molecular Biology, Constantine (DZ)
  • Amina ZIBOUCHE University of Brothers Mentouri, Faculty of Nature and Life Sciences, Department of Biochemistry and Biological Cellular and Molecular, Constantine (DZ)
  • Somia MEDJOUDJ University of Brothers Mentouri, Faculty of Nature and Life Sciences, Department of Biochemistry and Biological Cellular and Molecular, Constantine (DZ)
  • Sorayad GOUMEIDANE Infectiology Service of Ali Boushaba Public Hospitalier Khenchela (DZ)
  • Leila ROUABAH University of Brothers Mentouri, Laboratory of Cellular and Molecular Biology, Constantine (DZ)
Keywords: biochemical parameters, COVID-19, diabetes, hyperglycemia, mortality


The objectives of this study were to determine the biological characteristics of diabetic patients who have been diagnosed with COVID-19 and to estimate the risk of death in these patients. The study included 285 COVID-19 individuals whose diagnosis was confirmed by PCR and/or on the basis of typical signs and radiological findings (CT). Patients admitted to the Infectiology Service of Ali Boushaba Public Hospitalier Khenchela, during the year 2020. The data was collected from 1 January to 30 June 2021. The average age of patients diagnosed with COVID-19 in the enumerated population is 62.53 + 16.65 years. A male predominance was noted, with a sex ratio of men to women in the range of 1,29. Old diabetic patients account for 48.80 % of our sample patient. The PCR was positive in 87% of diabetic cases, the oxygen desaturation was 64.7%, and the pulmonary affliction was important or critical in 28.8% and 18.7%, respectively.  A wide range of biological abnormalities was found in diabetic patients, including high CRP in 95.7% of cases, hyperglycemia in 64%, hyperleucocytose in 26.6% of cases, D-dimer elevation in 56% of cases, and hypoprothrombinemia in 21.6% of cases. A high rate of urea and hypo-creatinemia were found in 36.70% and 12% of patients, respectively. As well as high rates of ASAL and ALAT in 28.80% and 26.60% of patients, respectively.  In diabetics a mortality rate of 22.3% was noted. With the exception of glycemia and ALAT, the differences in percentages of these parameters based on the presence of diabetes are statistically insignificant. Furthermore, the diabetic is unrelated to the clinical outcome of the patients. Due to the high number of infections, biological changes, and deaths among diabetics infected with COVID19, it is necessary to consider good care of care of these patients in order to reduce morbidity and mortality rates.


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Alzaid F, Julla JB, Diedisheim M (2020). Monocytopenia, monocyte morphological anomalies and hyperinflammation characterize sever COVID-19 in type 2 diabetes. EMBO Molecular Medicine 12:e13038.

Apicella M, Campopiano MC, Mantuano M, Mazoni L, Coppelli A, Del Prato S (2020). COVID- 19 in people with diabetes: understanding the reasons for worse outcomes. The Lancet Diabetes & Endocrinology 8(9):782-792.

Cariou B, Hadjadj S, Wargny M, Pichelin M, Al-Salameh A, Allix I, ... Gourdy P (2020). Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia 63:1500-1515.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet 395(10223):507-513.

Covid C, Team R, COVID C, Team R, Chow N, Fleming-Dutra K, ... Ussery E (2020). Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019-United States, February 12–March 28, 2020. Morbidity and Mortality Weekly Report 69(13):382.

Coppelli A, Giannarelli R, Aragona M, Penno G, Falcone M, Tiseo G, ... Del Prato S (2020). Hyperglycemia at hospital admission is associated with severity of the prognosis in patients hospitalized for COVID-19: the Pisa COVID-19 study. Diabetes Care 43(10):2345-2348.

Diao B, Wang C, Tan Y, Chen X, Liu Y, Ning L, ... Chen Y (2020). Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19). Frontiers in Immunology 11:827.

Epidemiology Working Group for Ncip Epidemic Response (2020). The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Chinese Journal of Epidemiology 41(2):145-51.

Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, ... Zou H (2020). Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. Journal of Infection 80(6):656-665.

Gao Y, Li T, Han M, Li X, Wu D, Xu Y, ... Wang L (2020). Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID‐19. Journal of Medical Virology 92(7):791-796.

Geerlings SE, Hoepelman AI (1999). Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunology & Medical Microbiology 26(3-4):259-265.

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, ... Zhong NS (2020). Clinical characteristics of coronavirus disease 2019 in China. New England Journal of Medicine 382(18):1708-1720.

Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, ... He JX (2020). Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. European Respiratory Journal 55(5).

Guo L, Shi Z, Zhang Y, Wang C, Moreira NCDV, Zuo H, Hussain A (2020). Comorbid diabetes and the risk of disease severity or death among 8807 COVID-19 patients in China: a meta-analysis. Diabetes Research and Clinical Practice 166:108346.

Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C, ... Hu D (2020). Diabetes is a risk factor for the progression and prognosis of COVID‐19. Diabetes/metabolism Research and Reviews 36(7):e3319.

Hussain A, Bhowmik B, do Vale Moreira NC (2020). COVID-19 and diabetes: Knowledge in progress. Diabetes Research and Clinical Practice 162:108142.

Levi M, Thachil J, Iba T, Levy JH (2020). Coagulation abnormalities and thrombosis in patients with COVID-19. The Lancet Haematology 7(6):e438-e440.

Lounici A, Benmekki A, Ghenou A, Tahir S, Belmimoune A, Zini S, ... Nigassa NB (2021). Particularités cliniques des patients diabétiques hospitalisés pour Covid-19 sur une période d’une année. Revue Algérienne d’Allergologie et d’Immunologie Clinique 6:2543-3555.

Luo X, Zhou W, Yan X, Guo T, Wang B, Xia H, ... Yang W (2020). Prognostic value of C-reactive protein in patients with coronavirus 2019. Clinical Infectious Diseases 71(16):2174-2179.

Malik P, Patel U, Mehta D, Patel N, Kelkar R, Akrmah M, ... Sacks H (2021). Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ Evidence-Based Medicine 26(3):107-108.

Orioli L, Hermans MP, Preumont V, Loumaye A, Thissen J-P, Alexopoulou O, Furnica R, Burlacu M-C, Maiter D, Yombi C-J, Vandeleene B (2020). COVID-19 et diabète. Louvain Medicine 139(05-06):252-257.

Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y (2020). Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 28;71(15):762-768.

Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, ... Sah R (2020). Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Medicine and Infectious Disease 34:101623.

Ruan Qk Yang K, Wang W, Jiang L, Song J (2020). Clinical predictors of mortality due to COVID-19 based on an analysis data of 150 patients from Wuhan, China. Intensive Care Medicine 1-3.

Salje H, Tran Kiem C, Lefrancq N, Courtejoie N, Bosetti P, Paireau J, ... Cauchemez S (2020). Estimating the burden of SARS-CoV-2 in France. Science 369(6500):208-211.

Scheen AJ, Marre M, Thivolet C (2020). Prognostic factors in patients with diabetes hospitalized for COVID-19: findings from the CORONADO study and other recent reports. Diabetes and Metabolism 46(4):265-271.

Schlesinger S, Neuenschwander M, Lang A, Pafili K, Kuss O, Herder C, Roden M (2021). Risk phenotypes of diabetes and association with COVID-19 severity and death: a living systematic review and meta-analysis. Diabetologia 64(7):1480-1491.

Singh AK, Gupta R, Ghosh A, Misra A (2020). Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14(4):303-310.

Tan L, Wang Q, Zhang D, Ding J, Huang Q, Tang YQ, ... Miao H (2020). Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduction and Targeted Therapy 5(1):1-3.

Tang N, Li D, Wang X, Sun Z (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis, 18(4):844-847.

Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, ... Bouillon R (2001). Intensive insulin therapy in critically ill patients. New England Journal of Medicine 345(19):1359-1367.

Wan Y, Shang J, Graham R, Baric RS, Li F (2020). Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. Journal of Virology 94(7):e00127-20.

Wang D, Hu B, Hu C (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 323(11):1061.

Wang S, Ma P, Zhang S, Song S, Wang Z, Ma Y, ... Jin Y (2020). Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study. Diabetologia 63(10):2102-2111.

Wu Z, McGoogan JM (2020). Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA 323:1239-1242.

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, ... Chen Q (2020). High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. International Journal of Oral Science 12(1):1-5.

Yang X, Yu Y, Xu J, Shu H, Liu H, Wu Y, ... Shang Y (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine 8(5) :475-481.

Zhang B, Liu S, Zhang L, Dong Y, Zhang S (2020). Admission fasting blood glucose predicts 30-day poor outcome in patients hospitalized for COVID-19 pneumonia. Vol. 22, Diabetes, Obesity and Metabolism. Blackwell Publishing Ltd. pp 1955-1957.

Zhang, J. J., Dong, X., Cao, Y. Y., Yuan, Y. D., Yang, Y. B., Yan, Y. Q., ... & Gao, Y. D. (2020). Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China. Allergy 75(7):1730-1741.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, ... Cao B (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet 395(10229):1054-1062.

How to Cite
ABED, N., ZIBOUCHE, A., MEDJOUDJ, S., GOUMEIDANE, S., & ROUABAH, L. (2022). Biological characteristics and mortality in patients with diabetes and COVID-19. Notulae Scientia Biologicae, 14(3), 11276.
Research articles
DOI: 10.55779/nsb14311276