Ethnopharmacological survey of medicinal plants used to treat cutaneous leishmaniasis in Ain Sekhouna, Saida, Algeria


  • Asmaa AMARI Djillali Liabes University Sidi-Bel-Abbès, Faculty of Nature and Life Sciences, Department of Environmental Sciences, Laboratory for the Eco-development of Spaces, BP 89, 22000 Sidi-Bel-Abbès (DZ)
  • Kadda HACHEM University of Saida - Dr. Tahar Moulay, Faculty of Sciences, Department of Biology, Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of Plants (LBPBVP), BP 138 ENNASR, 20000 Saida; University of Saida - Dr. Tahar Moulay, Faculty of Sciences, Department of Biology, BP 138 ENNASR, 20000 Saida (DZ)
  • Maya M. HASSANI University of Saida - Dr. Tahar Moulay, Faculty of Sciences, Department of Biology, BP 138 ENNASR, 20000 Saida (DZ)



Ain Sekhouna, Algeria, cutaneous leishmaniasis, ethnopharmacological survey, medicinal plant, natural remedy


Cutaneous leishmaniasis is a common anthropozoonosis and a major public health problem in Algeria. Therefore, we conducted an ethnopharmacological survey in the locality of Ain Sekhouna (located in the highlands of western Algeria), one of the foci of cutaneous leishmaniasis. We aimed to identify the medicinal plants and natural remedies used by the local population to treatment cutaneous leishmaniasis. We identified three plant species, belonging to three distinct families, used as natural remedies against the disease, namely, Haloxylon scoparium Pomel (Chenopodiaceae, 73%), Artemisia herba-alba Asso. (Asteraceae, 18%), and Camellia sinensis L. (Theaceae, 9%). Additionally, 35% of the plant-based medicines mostly comprised the powdered form of the aerial parts of the plant. According to the respondents, the powder is combined with butter, cade oil, or honey and is applied exogenously on the skin. Overall, these medicinal plants can be used as a source of natural medicines, in combination with commonly used dermatological excipients, to treat cutaneous leishmaniasis.


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Al-Qura’n S (2009). Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan. Journal of Ethnopharmacology 123:45-50.

Anteur D, Mederbal K, Belhacini FZ, Baghdadi D, Gourari B, Marouf B (2016). Diagnosis of the floristic diversity of Ain Sekhouna (Steppe West-Algerian). International Journal of Biosciences 9:292-296.

Bachi F (2006). Aspects épidémiologiques et cliniques des leishmanioses en Algérie [Epidemiological and clinical aspects of leishmaniasis in Algeria]. La Lettre de l’infectiologue 21:9-15.

Benabdesslem Y, Hachem K, Kahloula K, Slimani M (2017). Ethnobotanical survey, preliminary physico-chemical and phytochemical screening of Salvia argentea (L.) used by herbalists of the Saïda Province in Algeria. Plants 6:59.

Benarba B, Belabid L, Righi K, Bekkar AA, Elouissi M, Khaldi A, Hamimed A (2015). Ethnobotanical study of medicinal plants used by traditional healers in Mascara (North West of Algeria). Journal of Ethnopharmacology 175:626-637.

Bhutto AM, Soomro RA, Nonaka S, Hashiguchi Y (2003). Detection of new endemic areas of cutaneous leishmaniasis in Pakistan:a 6-year study. International Journal of Dermatology 42:543-548.

Bigo C (2011). La phytothérapie utilisée dans l’éréthisme cardiaque [Phytotherapy used in cardiac erethism]. PhD Thesis in Pharmacy, University of Lille,France.

Domerego R, Imbert, G, Blanchard C (2016). Guide pratique de la médecine des abeilles: miel, pollen, propolis, gelée royale... au quotidien [Practical guide to bee medicine: honey, pollen, propolis, royal jelly... in everyday life]. Baroch Eds, Norante, France.

Doukkali Z, Bouidida H, Srifi, A, Taghzouti K, Cherrah Y, Alaoui K (2015). Les plantes anxiolytiques au Maroc. Études ethnobotanique et ethno-pharmacologique [Anxiolytic plants in Morocco. Ethnobotanical and ethno-pharmacological study]. Phytothérapie 13:306-313.

El Rhaffari L, Hammani K, Benlyas M, Zaid A (2002). Traitement de la leishmaniose cutanée par la phytothérapie au Tafilalet [Treatment of cutaneous leishmaniasis by phytotherapy in Tafilalet]. Biologie et Santé 1:45-54.

Fontanel D (2012). Huiles et beurres de pulpes de fruits: revue des principales sources exploitées, teneurs en insaponifiables, propriétés et usages traditionnels d’intérêt cosmétique[Pulpy fruit oils and fats: Review of the main sources, unsaponifiable contents, properties and traditional uses related to interest incosmetics]. OCL-Oilseeds and fats, Crops and Lipids 19:232-237.

Grol M, Thomason TN, Franke ED (1992). Drug resistance in leishmaniasis: its implication in systemic chemotherapy of cutaneous and mucocutaneous disease. American Journal of Tropical Medicine and Hygiene 47:117-126.

Haida S, Kribii A, Kribii A (2020). Chemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts. South African Journal of Botany 131:151-160.

Hamza N, Berke B, Umar A, Cheze C, Gin H, Moore N (2019). A review of Algerian medicinal plants used in the treatment of diabetes. Journal of Ethnopharmacology 238:111841.

Harrat Z, Hamrioui B, Belkaid M, Tabet-Derraz O (1995). Point actuel sur l’épidémiologie des leishmanioses en Algerie [Current statuts on the epidemiology of leishmaniasis in Algeria]. Bulletin de la Société de Pathologie Exotique 88:180-184.

Hinds L, Kenny O, Hossain MB, Walsh D, Sheehy E, Evans P, Gaffney M, Rai DK (2017). Evaluating the antibacterial properties of polyacetylene and glucosinolate compounds with further identification of their presence within various carrot (Daucus carota) and broccoli (Brassica oleracea) cultivars using high-performance liquid chromatography with a diode array detector and ultra-performanceliquid chromatography-tandem mass spectrometry analyses. Journal of Agricultural and Food Chemistry 65:7186-7191.

Jaradat NA, Ayesh OI, Anderson C (2016). Ethnopharmacological survey about medicinal plants utilized by herbalists and traditional practitioner healers for treatments of diarrhoea in the West Bank/Palestine. Journal of Ethnopharmacology 182:57-66.

Jones J, Bowlig J, Waston J, Viga-Lopez F, White J, Higgins E (2005). Old-world cutaneous leishmaniasis infection in children: a case series. Archives of Disease in Childhood 9:530-531.

Koruk ST, Ozyilkan E, Kaya P, Colak D, Donderici O, Cesaretli Y (2005). Juniper tar poisoning. Clinical Toxicology 43:47-49.

Li Y, Plitzko I, Zaugg J, Hering S, Hamburger M (2010). HPLC-based activity profiling for GABA receptor modulators: a new dihydroisocoumarin from Haloxylon scoparium. Journal of Natural Products 73:768-770.

Mahmoudvand H, Sharififar F, Sharifi I, Ezatpour B, Fasihi Harandi M, Makki MS, Zia-Ali N, Jahanbakhsh S (2014). In vitro inhibitory effect of Berberis vulgaris (Berberidaceae) and its main component, berberine against different Leishmania species. Iranian Journal of Parasitology 9:28-36.

Manjolin LC, dos Reis MB, Maquiaveli CC, Santos-Filho OA, da Silva ER (2013). Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania amazonensis infection. Food Chemistry 141:2253-2262.

McGwire BS, Satoskar AR (2013). Leishmaniasis: clinical syndromes and treatment. QJM: An International Journal of Medicine 107:7-14.

Miara MD, Bendif H, Ait Hammou H, Teixidor-Toneu I (2018). Ethnobotanical survey of medicinal plants used by nomadic peoples in the Algerian steppe. Journal of Ethnopharmacology 219:248-256.

Rhattas M, Douira A, Zidane L (2016). Étude ethnobotanique des plantes médicinales dans le Parc National de Talassemtane (Rif occidental du Maroc) [Ethnobotanical study of medicinal plants in the Talassemtane Natural Park (Western Rif of Morocco)]. Journal of Applied Biosciences 97:9187-9211.

Salhi S, Fadli M, Zidane L, Douira A (2010). Etudes floristique et ethnobotanique des plantes médicinales de la ville de Kénitra (Maroc) [Floristic and ethnobotanical study of medicinal plants of Kénitra (Maroc)]. Lazaroa 31:133-146.

Tabuti JRS, lye KA, Dhillion SS (2003). Traditional herbal drugs of Bulamogi, Uganda: plants, use and administration. Journal of Ethnopharmacology 88:19-44.

Uzuna E, Sariyar G, Adsersen A, Karacok B, Ötük G, Oktayuglo E, Pirildar S (2004). Traditional medicine in Sakarya province (Turkey) and antimicrobial activities of selected species. Journal of Ethnopharmacology 95:287-296.

Vandi D, Nga EN, Betti JL, Loe GME, Ottou PBM, Priso RJ, Foze TN, Boumsong PCN, Dibong SD, Mpondo EM (2016). Contribution des populations des villes de Yaoundé et Douala à la connaissance des plantes à tanins et à anthocyanes[Contribution of the populations of the cities of Yaoundé and Douala to the knowledge of tannin and anthocyanin plants]. Journal of Animal and Plant Sciences 30:4797-4814.

Wubetu M, Abula T, Dejenu G (2017). Ethnopharmacological survey of medicinal plants used to treat human diseases by traditional medical practitioners in Dega Damot district, Amhara, Northwestern Ethiopia. BMC Research Notes 10:157.

Zeggwagh AA, Lahlou Y, Bousliman Y (2013). Survey of toxicological aspects of herbal medicine used by an herbalist in Fes, Morocco. Pan African Medical Journal 14:125.

Zeouk I, El Ouali Lalami A, Ezzoubi Y, Derraz K, Balouiri M, Bekhti K (2020). Cutaneous leishmaniasis: medicinal plants used in Sefrou city (Centre of Morocco), a focus of leishmaniasis. Phytothérapie 18:187-194.




How to Cite

AMARI, A., HACHEM, K. ., & HASSANI, M. M. . (2021). Ethnopharmacological survey of medicinal plants used to treat cutaneous leishmaniasis in Ain Sekhouna, Saida, Algeria. Notulae Scientia Biologicae, 13(2), 10961.



Research articles
DOI: 10.15835/nsb13210961