Curcumin Alleviates Potassium Bromate-Induced Hepatic Damage by Repressing CRP Induction through TNF-α and IL-1βand by Suppressing Oxidative Stress

  • Omowumi O. ADEWALE Osun State University, Faculty of Basic and Applied Sciences, Department of Biochemistry, Cancer Research and Molecular Toxicology Laboratories, Osogbo (NG)
  • Seun F. AKOMOLAFE Ekiti State University, Faculty of Science, Department of Biochemistry, Ado Ekiti (NG)
  • Nnaemeka T. ASOGWA Central Research Laboratories, Ilorin, Kwara State (NG)
Keywords: C-reactive protein; curcumin; cytokines; hepatoprotective; potassium bromate


This study evaluated the prospective molecular and bi ochemical mechanisms behind the hepatoprotective effec ts of curcumin in Wistar rats exposed to KBrO 3. Techniques for assessment of hepatic oxidative injury and histological biomarkers were used. The concentrations of proteins connected w ith inflammation (e.g. tumor necrosis factor-alpha (T NF-α), interleukins 1β (IL-1β) and C-reactive protein (CRP) ) were estimated by enzyme-linked immunosorbent assay (E LISA) techniques. Results showed that, curcumin administered or ally at a dose of 20 mg/kg for 28 days significantly supp ressed the activities of serum transaminases and alkaline induced by KBrO 3 administration (20 mg/kg, twice weekly) and protecte d the integrity of the liver tissue. Also, curcumin at the te sted dose abridged the KBrO 3 -induced increase in hepatic malondialdehyde (MDA) levels and reversed KBrO 3 mediated reduction in activities of hepatic antiox idant molecules including reduced glutathione (GSH), total thiol (TSH), glutathione pero xidase (GPx), catalase and superoxide dismutase (SOD). I n addition, curcumin significantly assuaged inflammatory response in KBrO 3 -lesioned liver as revealed by the decrease in inflammato ry biomarkers. This study suggests that curcumin exhibits a protective effect via induction of hepatic detoxification prot eins and inhibition of inflammatory proteins in addition to i ts antioxidative ability in KBrO 3 - induced hepatic injury in rats.


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How to Cite
ADEWALE, O. O., AKOMOLAFE, S. F., & ASOGWA, N. T. (2019). Curcumin Alleviates Potassium Bromate-Induced Hepatic Damage by Repressing CRP Induction through TNF-α and IL-1βand by Suppressing Oxidative Stress. Notulae Scientia Biologicae, 11(4), 337-344.
Research articles
DOI: 10.15835/nsb11410552