Evaluation of Various Biological Activities of Endemic Sideritis libanotica Extracts


  • Mehmet ATAS Sivas Cumhuriyet University, Faculty of Pharmacy, Pharmaceutical Microbiology Department, 58140, Sivas (TR)
  • Nuraniye ERUYGUR Selcuk University, Department of Pharmacognosy, Faculty of Pharmacy, Konya (TR)
  • Fazli SOZMEN Sivas Cumhuriyet University, Faculty of Engineering, Nanotechnology Engineering Department, 58140, Sivas (TR)
  • Mustafa ERGUL Sivas Cumhuriyet University, Faculty of Pharmacy, Biochemistry Department, 58140, Sivas (TR)
  • Merve ERGUL Sivas Cumhuriyet University, Faculty of Pharmacy, Pharmacology Department, 58140, Sivas (TR)
  • Huseyin Askin AKPULAT Sivas Cumhuriyet University, Department of Biology, Faculty of Education, Sivas (TR)
  • Esra UCAR Sivas Cumhuriyet University, Vocational School, Medicinal and Aromatic Plant Department, 58140, Sivas (TR)




antioxidants; biological activities; enzyme inhibition; Sideritis libanotica


In recent years, using of plants to develop combine therapies for treatment of certain diseases such as cancer, Alzheimer's disease, and diabetes mellitus is extremely plausible approach. Perhaps, the definitive treatment of some of these diseases is hidden in the complex content of a plant in nature. Thus, in the present study, we decided to determine the biological activities of methanol and water extracts of the endemic Sideritis libanotica. To the best of our knowledge, the present study is the first investigation on antioxidant, enzyme inhibitory activity, antimicrobial activity, and in vitro cytotoxicity of S. libanotica. According to results, while the methanol extract shows better anti-cholinesterase, α-glucosidase, and α-amylase inhibition activity and cytotoxicity than the water extract, the tyrosinase inhibitory activity of the water extract was found to be better than the methanol extract. This study provides valuable information on how the biological activity of endemic S. libanotica changes in different solvent extractions such as water and methanol.


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How to Cite

ATAS, M., ERUYGUR, N., SOZMEN, F. ., ERGUL, M., ERGUL, M., AKPULAT, H. A. ., & UCAR, E. (2019). Evaluation of Various Biological Activities of Endemic Sideritis libanotica Extracts. Notulae Scientia Biologicae, 11(2), 210–217. https://doi.org/10.15835/nsb11210442



Research articles
DOI: 10.15835/nsb11210442