Methanolic Extracts of Cochorous olitorous (L.) and Adansonia digitata (L.) Leaves Against Irradiation-Induced Atherosclerosis in Male Wistar Rats

  • Kabir O. BELLO University of Ilorin, Faculty of Life Sciences, Department of Biochemistryn (NG) http://orcid.org/0000-0001-5759-0636
  • Sarah O. NWOZO University of Ibadan,Faculty of Basic Medical Sciences, Department of Biochemistry,
  • Johnson OLADELE Osun State University, College of Pure and Applied Sciences,Department of Biochemistry
  • Kabir K. MUSTAPHA University of Ilorin, Faculty of Life Sciences, Department of Biochemistryn
  • Lukman A. QUADRI University of Ilorin, Faculty of Life Sciences, Department of Biochemistryn

Abstract

The present study investigated the anti-atherosclerotic and antioxidative effect of the methanolic extracts (MExt) of Cochorous olitorous (CO) and Adansonia digitata (AD) leaves on irradiation-induced atherosclerosis in male Wistar rats. Atherosclerosis was induced in male rats by a single dose of 6 gray whole body gamma radiation. MExt of C. olitorous and A. digitata leaves at 500 and 1,000 mg/kg bwt were administered as treatment for 7 days. Blood serum was analysed for lipid profile, MDA (malondialdehyde) and liver tissue for antioxidants enzymes, whereas the therapeutic potential was compared to the lipids-lowering drug lovastatin at 10 mg/kg/bwt. The phytochemical studies showed the presence of polyphenols, flavonoids, tannins and saponins. Treatment with MExt of CO and AD normalized the elevated MDA level, whereas the activities of superoxide dismutase, catalase and glutathione peroxidase in the treated rats increased. Pronounced changes were observed at 1,000 mg/kg bwt mixture of MExt of CO and AD for 1 weeks and it was more potent than the standard drug. The current study provided strong evidence that MExt of CO and AD might be important in the treatment of atherosclerosis and ROS without any side effects at the studied dosage and duration.

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Published
2017-06-30
How to Cite
BELLO, K. O., NWOZO, S. O., OLADELE, J., MUSTAPHA, K. K., & QUADRI, L. A. (2017). Methanolic Extracts of Cochorous olitorous (L.) and Adansonia digitata (L.) Leaves Against Irradiation-Induced Atherosclerosis in Male Wistar Rats. Notulae Scientia Biologicae, 9(2), 182-187. https://doi.org/10.15835/nsb9210046
Section
Research articles
CITATION
DOI: 10.15835/nsb9210046